Sucrose-derived exopolymers have site-dependent roles inStreptococcus mutans-promoted dental decay

Sucrose-derived exopolymers have site-dependent roles in Streptococcus mutans-promoted dental decay.

We have constructed a panel of mutants of S. mutans V403 which are defective in one or more of the glucosyltransferase genes (gtfB, C or D) or the fructosyltransferase gene (ftf). These strains have been tested for virulence in a gnotobiotic rat caries model with reference to both buccal (smooth surface) and sulcal (pit and fissure) carious lesions. Our data suggest differing roles for degradab...

Low sucrose levels promote extensive Streptococcus mutans-induced dental caries.

One-tenth percent sucrose significantly promotes dental caries induced by Streptococcus mutans in young gnotobiotic rats. Maximum caries activity was observed in rats provided a purified diet containing 3% sucrose.

Role of Streptococcus mutans in human dental decay.

In situ study of sucrose exposure, mutans streptococci in dental plaque and dental caries.

The purpose of this study was to investigate the relationship among frequency of sucrose exposure, mutans streptococci levels and dental caries. Adult volunteers took part in this crossover study performed in 4 phases of 28 days each. The volunteers wore intra-oral palatal appliances containing blocks of human dental enamel and dripped 20% sucrose solution onto the dental blocks from 0 to 8 tim...

Physiological roles of regulated Ire1 dependent decay

Inositol-requiring enzyme 1 (Ire1) is an important transducer of the unfolded protein response (UPR) that is activated by the accumulation of misfolded proteins in the endoplamic reticulum (ER stress). Activated Ire1 mediates the splicing of an intron from the mRNA of Xbp1, causing a frame-shift during translation and introducing a new carboxyl domain in the Xbp1 protein, which only then become...